probiotics: an update on mechanisms of action and clinical applications
نویسندگان
چکیده
probiotics are live microbial feed supplement and can provide health benefit to the host if administered in sufficient amounts. the most predominant species that have been used as probiotic include lactobacilli and bifidobacteria. proper administration of probiotics could be efficient in the treatment of various disorders. however; their mechanism of action is poorly understood. the effects of probiotics may be classified in following modes: reinforcement of the intestinal mucosal barrier against pathogens, competition with pathogens for adherence to the mucosa and epithelium, competitive exclusion of pathogenic microorganisms, production of antimicrobial substances, modulation of the immune system and interference with quorum sensing signaling. exploration of the clinical features of probiotic strains, their modes of action and investigation based on probiotic therapy may be beneficial in treatment of various diseases.
منابع مشابه
Probiotics: an update on mechanisms of action and clinical applications
Probiotics are live microbial feed supplement and can provide health benefit to the host if administered in sufficient amounts. The most predominant species that have been used as probiotic include Lactobacilli and bifidobacteria. Proper administration of probiotics could be efficient in the treatment of various disorders. However; their mechanism of action is poorly understood. The effects of ...
متن کاملProbiotics: Mechanisms of Action and Clinical Applications
Recent research has revealed a potential therapeutic role for the manipulation of the microbiota in the maintenance of human health and treatment of various mucosal disorders. Probiotic microorganisms can shape the immune system both at the local and systemic level which will allow future probiotics as treatments for many diseases. The benefits include either a shortened duration of infections ...
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The concept of prebiotics, probiotics, and symbiotics and their use in different situations of daily clinical practice related to clinical nutrition is reviewed, as well as their role in the treatment/prevention of diarrhea (acute, induced by antibiotics, secondary to radiotherapy), inflammatory bowel disease (ulcerative colitis and pouchitis), in colonic health (constipation, irritable bowel),...
متن کاملMechanisms of action of probiotics.
At birth, the newborn leaves the germ-free intrauterine environment and enters a highly contaminated extrauterine world, which requires potent host defenses to prevent disease. Intestinal defenses develop during gestation and have the capacity to respond but first must be exposed to colonizing bacteria. I review the importance of bacterial colonization for the appearance of normal mucosal immun...
متن کاملClinical Applications of Probiotics
For some decades now, bacteria known as probiotics have been added to various foods because of their beneficial effects for human health. Examples of foods containing probiotics are yogurt, fermented and unfermented milk, miso, tempeh, soy beverages and some juices. Lactic acid bacteria (LAB) and bifidobacteria are the most common types of microbes used as probiotics; but certain yeasts and bac...
متن کاملProbiotics: an update.
OBJECTIVE Triggered by the growing knowledge on the link between the intestinal microbiome and human health, the interest in probiotics is ever increasing. The authors aimed to review the recent literature on probiotics, from definitions to clinical benefits, with emphasis on children. SOURCES Relevant literature from searches of PubMed, CINAHL, and recent consensus statements were reviewed. ...
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عنوان ژورنال:
novelty in biomedicineجلد ۲، شماره ۱، صفحات ۲۲-۳۰
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